| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50392675 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_854194 (CHEMBL2154211) |
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| IC50 | 890±n/a nM |
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| Citation |  Ammazzalorso, A; D'Angelo, A; Giancristofaro, A; De Filippis, B; Di Matteo, M; Fantacuzzi, M; Giampietro, L; Linciano, P; Maccallini, C; Amoroso, R Fibrate-derived N-(methylsulfonyl)amides with antagonistic properties on PPARa. Eur J Med Chem58:317-22 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50392675 |
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| n/a |
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| Name | BDBM50392675 |
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| Synonyms: | CHEMBL2153835 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15ClN2O3S3 |
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| Mol. Mass. | 378.918 |
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| SMILES | CCCC(Sc1nc2cc(Cl)ccc2s1)C(=O)NS(C)(=O)=O |
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| Structure | 
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