| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Telomerase reverse transcriptase |
|---|
| Ligand | BDBM50396098 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_864817 (CHEMBL2175306) |
|---|
| IC50 | 3060±n/a nM |
|---|
| Citation |  Cohn, EP; Wu, KL; Pettus, TR; Reich, NO A new strategy for detection and development of tractable telomerase inhibitors. J Med Chem55:3678-86 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Telomerase reverse transcriptase |
|---|
| Name: | Telomerase reverse transcriptase |
|---|
| Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 127099.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1447029 |
|---|
| Residue: | 1132 |
|---|
| Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
|
|
|
|---|
| BDBM50396098 |
|---|
| n/a |
|---|
| Name | BDBM50396098 |
|---|
| Synonyms: | CHEMBL2170857 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H20O12 |
|---|
| Mol. Mass. | 536.4405 |
|---|
| SMILES | COC(=O)c1cc2cc3CC[C@]4(CC5=C(O4)C(=O)c4c(O)c(OC)cc(OC)c4C5=O)Oc3c(O)c2c(=O)o1 |r,c:13| |
|---|
| Structure | 
|
|---|
Search and Browse
