| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin D3 receptor |
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| Ligand | BDBM50397221 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_864384 (CHEMBL2175861) |
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| EC50 | 5.74±n/a nM |
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| Citation |  Carballa, DM; Seoane, S; Zacconi, F; Pérez, X; Rumbo, A; Alvarez-Díaz, S; Larriba, MJ; Pérez-Fernández, R; Muñoz, A; Maestro, M; Mouriño, A; Torneiro, M Synthesis and biological evaluation of 1a,25-dihydroxyvitamin D3 analogues with a long side chain at C12 and short C17 side chains. J Med Chem55:8642-56 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin D3 receptor |
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| Name: | Vitamin D3 receptor |
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| Synonyms: | 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR | VDR_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 48288.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11473 |
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| Residue: | 427 |
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| Sequence: | MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS
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| BDBM50397221 |
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| n/a |
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| Name | BDBM50397221 |
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| Synonyms: | CHEMBL2172537 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H56O4 |
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| Mol. Mass. | 516.7953 |
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| SMILES | C[C@H](CCCO)[C@H]1CC[C@H]2\C(CC[C@@H](CCCCCCC(C)(C)O)[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |r| |
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| Structure | 
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