Reaction Details |
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Target | Apoptosis regulator Bcl-2 |
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Ligand | BDBM50397474 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_862012 (CHEMBL2173962) |
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IC50 | 621±n/a nM |
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Citation | Chen, J; Zhou, H; Aguilar, A; Liu, L; Bai, L; McEachern, D; Yang, CY; Meagher, JL; Stuckey, JA; Wang, S Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem55:8502-14 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Apoptosis regulator Bcl-2 |
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Name: | Apoptosis regulator Bcl-2 |
Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
Type: | Homodimer or heterodimer |
Mol. Mass.: | 26269.11 |
Organism: | Homo sapiens (Human) |
Description: | P10415 |
Residue: | 239 |
Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM50397474 |
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n/a |
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Name | BDBM50397474 |
Synonyms: | CHEMBL2171008 |
Type | Small organic molecule |
Emp. Form. | C45H54ClN7O3S |
Mol. Mass. | 808.473 |
SMILES | CCc1cccc(c1)S(=O)(=O)Nc1ccc(cc1)N1CCN(CC1)c1cccc(c1)-c1c(C(=O)NCCCN2CCN(C)CC2)c(C)n(C)c1-c1ccc(Cl)cc1 |
Structure |
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