Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Prostaglandin D2 receptor 2 | ||
Ligand | BDBM50401098 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_884446 (CHEMBL2212208) | ||
IC50 | >1000±n/a nM | ||
Citation | Kaila, N; Huang, A; Moretto, A; Follows, B; Janz, K; Lowe, M; Thomason, J; Mansour, TS; Hubeau, C; Page, K; Morgan, P; Fish, S; Xu, X; Williams, C; Saiah, E Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. J Med Chem55:5088-109 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Prostaglandin D2 receptor 2 | |||
Name: | Prostaglandin D2 receptor 2 | ||
Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) | ||
Type: | Enzyme | ||
Mol. Mass.: | 43295.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9Y5Y4 | ||
Residue: | 395 | ||
Sequence: |
| ||
BDBM50401098 | |||
n/a | |||
Name | BDBM50401098 | ||
Synonyms: | CHEMBL2205158 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H23N3O3 | ||
Mol. Mass. | 437.4898 | ||
SMILES | Cc1c(-c2nn(Cc3ccccc3)c(=O)c3ccccc23)c2ccccc2n1CCC(O)=O |(22.19,-53.06,;20.65,-53.06,;19.74,-51.8,;20.51,-50.48,;22.05,-50.48,;22.83,-49.16,;24.37,-49.16,;25.13,-50.5,;24.35,-51.82,;25.11,-53.16,;26.65,-53.16,;27.43,-51.82,;26.66,-50.49,;22.06,-47.82,;22.84,-46.49,;20.52,-47.81,;19.75,-46.48,;18.2,-46.48,;17.43,-47.83,;18.2,-49.16,;19.74,-49.15,;18.26,-52.28,;16.93,-51.52,;15.6,-52.29,;15.59,-53.83,;16.93,-54.6,;18.26,-53.83,;19.74,-54.31,;20.21,-55.78,;19.18,-56.92,;17.68,-56.6,;17.19,-55.14,;16.64,-57.75,)| | ||
Structure |