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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Prostaglandin D2 receptor 2 | ||
| Ligand | BDBM50401105 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_884446 (CHEMBL2212208) | ||
| IC50 | >1000±n/a nM | ||
| Citation |  Kaila, N; Huang, A; Moretto, A; Follows, B; Janz, K; Lowe, M; Thomason, J; Mansour, TS; Hubeau, C; Page, K; Morgan, P; Fish, S; Xu, X; Williams, C; Saiah, E Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. J Med Chem55:5088-109 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Prostaglandin D2 receptor 2 | |||
| Name: | Prostaglandin D2 receptor 2 | ||
| Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 43295.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9Y5Y4 | ||
| Residue: | 395 | ||
| Sequence: |
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| BDBM50401105 | |||
| n/a | |||
| Name | BDBM50401105 | ||
| Synonyms: | CHEMBL2205151 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H22N4O2 | ||
| Mol. Mass. | 422.4785 | ||
| SMILES | Cc1c(-c2nn(Cc3ccccc3)c(=O)c3ccccc23)c2ccccc2n1CC(N)=O |(7.37,-22.45,;5.83,-22.45,;4.92,-21.19,;5.69,-19.87,;7.23,-19.88,;8.01,-18.55,;9.55,-18.55,;10.31,-19.89,;9.53,-21.21,;10.29,-22.55,;11.83,-22.56,;12.61,-21.22,;11.84,-19.89,;7.24,-17.21,;8.02,-15.88,;5.7,-17.21,;4.93,-15.87,;3.38,-15.87,;2.61,-17.22,;3.39,-18.55,;4.93,-18.55,;3.45,-21.67,;2.11,-20.91,;.78,-21.68,;.78,-23.22,;2.11,-23.99,;3.45,-23.22,;4.92,-23.7,;5.4,-25.17,;4.37,-26.31,;2.86,-25.99,;4.84,-27.78,)| | ||
| Structure | 
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