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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50402493 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_886649 (CHEMBL2216234) | ||
| Ki | 11±n/a nM | ||
| Citation |  Hunt, HJ; Ray, NC; Hynd, G; Sutton, J; Sajad, M; O'Connor, E; Ahmed, S; Lockey, P; Daly, S; Buckley, G; Clark, RD; Roe, R; Blasey, C; Belanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett22:7376-80 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
| ||
| BDBM50402493 | |||
| n/a | |||
| Name | BDBM50402493 | ||
| Synonyms: | CHEMBL2204048 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H22Cl2N2O2 | ||
| Mol. Mass. | 429.339 | ||
| SMILES | Clc1ccc(Cc2c([nH]c(=O)[nH]c2=O)[C@@H]2CC[C@@H](CC2)c2ccccc2)c(Cl)c1 |r,wU:14.14,17.21,(64.01,-42.17,;64,-43.7,;62.65,-44.46,;62.65,-46,;63.98,-46.79,;63.98,-48.35,;62.65,-49.13,;62.65,-50.69,;61.31,-51.45,;59.97,-50.69,;58.62,-51.48,;59.97,-49.14,;61.32,-48.37,;61.32,-46.83,;63.96,-51.46,;63.96,-53,;65.27,-53.77,;66.61,-53.01,;66.61,-51.47,;65.29,-50.69,;67.94,-53.79,;69.27,-53.03,;70.59,-53.8,;70.59,-55.35,;69.25,-56.11,;67.94,-55.33,;65.34,-46.03,;66.67,-46.81,;65.34,-44.49,)| | ||
| Structure | 
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