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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50402496 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_886649 (CHEMBL2216234) | ||
| Ki | 9±n/a nM | ||
| Citation |  Hunt, HJ; Ray, NC; Hynd, G; Sutton, J; Sajad, M; O'Connor, E; Ahmed, S; Lockey, P; Daly, S; Buckley, G; Clark, RD; Roe, R; Blasey, C; Belanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett22:7376-80 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
| ||
| BDBM50402496 | |||
| n/a | |||
| Name | BDBM50402496 | ||
| Synonyms: | CHEMBL2204045 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H26N2O3 | ||
| Mol. Mass. | 390.4748 | ||
| SMILES | COc1ccccc1Cc1c([nH]c(=O)[nH]c1=O)[C@@H]1CC[C@@H](CC1)c1ccccc1 |r,wU:17.18,20.25,(12.38,-46.43,;11.04,-47.19,;9.72,-46.41,;9.72,-44.86,;8.37,-44.08,;7.03,-44.84,;7.03,-46.38,;8.36,-47.16,;8.36,-48.72,;7.02,-49.51,;7.02,-51.06,;5.68,-51.83,;4.35,-51.06,;3,-51.85,;4.35,-49.51,;5.7,-48.74,;5.7,-47.2,;8.34,-51.83,;8.34,-53.37,;9.65,-54.15,;10.99,-53.39,;10.99,-51.85,;9.67,-51.06,;12.32,-54.17,;13.64,-53.4,;14.97,-54.18,;14.97,-55.72,;13.63,-56.48,;12.32,-55.7,)| | ||
| Structure | 
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