Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | ATP-dependent translocase ABCB1 | ||
Ligand | BDBM50410914 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_357500 (CHEMBL866963) | ||
IC50 | 2550±n/a nM | ||
Citation | Bisi, A; Gobbi, S; Rampa, A; Belluti, F; Piazzi, L; Valenti, P; Gyemant, N; Molnár, J New potent P-glycoprotein inhibitors carrying a polycyclic scaffold. J Med Chem49:3049-51 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
ATP-dependent translocase ABCB1 | |||
Name: | ATP-dependent translocase ABCB1 | ||
Synonyms: | ABCB1 | MDR1 | MDR1_HUMAN | Multidrug Resistance Transporter MDR 1 | Multidrug resistance protein 1 | Multidrug resistance protein 1/Multidrug resistance associated protein 1 | P-glycoprotein (P-gp) | P-glycoprotein 1 | PGY1 | ||
Type: | Protein | ||
Mol. Mass.: | 141503.50 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08183 | ||
Residue: | 1280 | ||
Sequence: |
| ||
BDBM50410914 | |||
n/a | |||
Name | BDBM50410914 | ||
Synonyms: | CHEMBL209247 | ||
Type | Small organic molecule | ||
Emp. Form. | C33H32N2O4 | ||
Mol. Mass. | 520.6182 | ||
SMILES | COc1ccc(CCN(C)CC#CCN2C(=O)C3C(C4c5ccccc5C3c3ccccc43)C2=O)cc1OC |TLB:21:20:32.27:18.17,31:32:25.20:18.17,THB:15:17:25.20:32.27,24:25:32.27:18.17,33:18:25.20:32.27,(8.03,6.81,;6.77,6.47,;6.43,5.21,;5.17,4.87,;4.84,3.61,;5.76,2.7,;5.42,1.44,;4.16,1.11,;3.82,-.15,;4.74,-1.08,;2.56,-.49,;1.64,.44,;.72,1.36,;-.2,2.3,;-1.48,1.98,;-1.97,.75,;-.7,1.1,;-3.28,.84,;-3.61,2.11,;-3.92,.32,;-5.63,-.17,;-6.97,.59,;-8.3,-.18,;-8.3,-1.73,;-6.96,-2.5,;-5.61,-1.72,;-3.83,-1.22,;-2.42,-2.11,;-1.01,-2.8,;.29,-1.93,;.18,-.36,;-1.22,.33,;-2.52,-.54,;-2.49,2.82,;-2.41,4.13,;7.02,3.03,;7.36,4.29,;8.61,4.62,;9.53,3.7,)| | ||
Structure |