| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Ligand | BDBM50241305 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_456375 (CHEMBL906422) |
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| IC50 | 1.05±n/a nM |
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| Citation |  Yoo, J; Thai, KM; Kim, DK; Lee, JY; Park, HJ 3D-QSAR studies on sildenafil analogues, selective phosphodiesterase 5 inhibitors. Bioorg Med Chem Lett17:4271-4 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase 2 and 5 (PDE2 and PDE5) | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Type: | Protein |
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| Mol. Mass.: | 99975.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O76074 |
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| Residue: | 875 |
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| Sequence: | MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
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| BDBM50241305 |
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| n/a |
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| Name | BDBM50241305 |
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| Synonyms: | (2-{4-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxy-benzenesulfonyl]-piperazin-1-yl}-ethyl)-phosphonic acid diethyl ester | CHEMBL246536 | diethyl 2-(4-(3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenylsulfonyl)piperazin-1-yl)ethylphosphonate |
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| Type | Small organic molecule |
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| Emp. Form. | C28H43N6O7PS |
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| Mol. Mass. | 638.716 |
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| SMILES | CCCOc1ccc(cc1-c1nc2c(CCC)nn(C)c2c(=O)[nH]1)S(=O)(=O)N1CCN(CCP(=O)(OCC)OCC)CC1 |
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| Structure | 
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