Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50192676 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_474247 (CHEMBL934096) | ||
IC50 | 43.65±n/a nM | ||
Citation | Lee, JH; Kang, NS; Yoo, SE Docking-based 3D-QSAR study for 11beta-HSD1 inhibitors. Bioorg Med Chem Lett18:2479-90 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50192676 | |||
n/a | |||
Name | BDBM50192676 | ||
Synonyms: | (3r,9r)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxylic acid | CHEMBL374409 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H33F3N4O3 | ||
Mol. Mass. | 482.539 | ||
SMILES | CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CCCC1C[C@H](C2)C(O)=O |wU:29.34,wD:22.23,TLB:21:22:26.25.24:30.29.28,31:29:26.25.24:22,(2.38,-31.91,;1.05,-31.13,;-.3,-31.88,;2.38,-30.36,;3.72,-31.14,;5.05,-30.38,;5.06,-28.84,;3.73,-28.07,;2.39,-28.83,;6.39,-28.08,;6.4,-26.54,;7.73,-25.78,;9.07,-26.55,;9.06,-28.09,;7.73,-28.86,;10.41,-25.79,;11.73,-25,;11.18,-27.12,;9.63,-24.45,;-.28,-30.36,;-.28,-28.82,;-1.62,-31.13,;-2.94,-30.36,;-3.96,-31.16,;-3.84,-32.92,;-4.66,-33.85,;-3.21,-33.8,;-3.19,-31.84,;-4.96,-31.86,;-6.07,-32.63,;-5.66,-31.16,;-7.4,-31.86,;-7.41,-30.31,;-8.75,-32.63,)| | ||
Structure |