| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
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| Ligand | BDBM50417448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_687867 (CHEMBL1291431) |
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| IC50 | 63.1±n/a nM |
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| Citation |  Stocks, MJ; Alcaraz, L; Bailey, A; Bowers, K; Donald, D; Edwards, H; Hunt, F; Kindon, N; Pairaudeau, G; Theaker, J; Warner, DJ The discovery of new spirocyclic muscarinic M3 antagonists. Bioorg Med Chem Lett20:7458-61 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M2 |
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| Name: | Muscarinic acetylcholine receptor M2 |
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| Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 |
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| Type: | GPCR |
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| Mol. Mass.: | 51730.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08172 |
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| Residue: | 466 |
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| Sequence: | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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| BDBM50417448 |
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| n/a |
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| Name | BDBM50417448 |
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| Synonyms: | CHEMBL1289202 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23ClN2O3 |
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| Mol. Mass. | 374.861 |
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| SMILES | Clc1ccc(CN2CCC3(CC2)CN(CCO3)C(=O)c2ccoc2)cc1 |
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| Structure | 
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