Reaction Details |
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Target | NAD-dependent protein deacetylase sirtuin-1 |
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Ligand | BDBM42882 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_934585 (CHEMBL2317546) |
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IC50 | >300000±n/a nM |
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Citation | Wu, J; Li, Y; Chen, K; Jiang, H; Xu, MH; Liu, D Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: binding mode, inhibitory mechanism and biological action. Eur J Med Chem60:441-50 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent protein deacetylase sirtuin-1 |
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Name: | NAD-dependent protein deacetylase sirtuin-1 |
Synonyms: | NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2 |
Type: | Developmental protein; hydrolase |
Mol. Mass.: | 81626.66 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 747 |
Sequence: | MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
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BDBM42882 |
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n/a |
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Name | BDBM42882 |
Synonyms: | (2,5-dimethoxyphenyl)-(5-hydroxy-1-benzofuran-3-yl)methanone | (2,5-dimethoxyphenyl)-(5-hydroxy-3-benzofuranyl)methanone | (2,5-dimethoxyphenyl)-(5-hydroxybenzofuran-3-yl)methanone | (2,5-dimethoxyphenyl)-(5-oxidanyl-1-benzofuran-3-yl)methanone | MLS000105566 | SMR000102447 | cid_626866 |
Type | Small organic molecule |
Emp. Form. | C17H14O5 |
Mol. Mass. | 298.2901 |
SMILES | COc1ccc(OC)c(c1)C(=O)c1coc2ccc(O)cc12 |
Structure |
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