BindingDB PrimarySearch

Found 73 hits with Last Name = 'xu' and Initial = 'mh'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044816 (CHEMBL1576457) Show SMILES c1coc(c1)-c1nnc2sc(nn12)-c1ccccn1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50425971 (CHEMBL2314710) Show SMILES Oc1ccc(O)c(c1)C(=O)c1coc2ccc(O)cc12 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Mixed-type inhibition of N-terminal His6-tagged SIRT1 coding region (156-664) (unknown origin) expressed in Escherichia coli BL21(DE3) using NAD+ as ...				Eur J Med Chem 60: 441-50 (2013) Article DOI: 10.1016/j.ejmech.2012.12.026 BindingDB Entry DOI: 10.7270/Q2WW7K0B
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044816 (CHEMBL1576457) Show SMILES c1coc(c1)-c1nnc2sc(nn12)-c1ccccn1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.41E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human SIRT1 F414A mutant expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate assessed as inhibit...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044816 (CHEMBL1576457) Show SMILES c1coc(c1)-c1nnc2sc(nn12)-c1ccccn1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.91E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human SIRT1 I347A mutant expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate assessed as inhibit...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044816 (CHEMBL1576457) Show SMILES c1coc(c1)-c1nnc2sc(nn12)-c1ccccn1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.89E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human SIRT1 F273L mutant expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate assessed as inhibit...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50425971 (CHEMBL2314710) Show SMILES Oc1ccc(O)c(c1)C(=O)c1coc2ccc(O)cc12 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged SIRT1 coding region (156-664) (unknown origin) expressed in Escherichia coli BL21(DE3) using 31.25 uM ac-RHKKac-...				Eur J Med Chem 60: 441-50 (2013) Article DOI: 10.1016/j.ejmech.2012.12.026 BindingDB Entry DOI: 10.7270/Q2WW7K0B
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044816 (CHEMBL1576457) Show SMILES c1coc(c1)-c1nnc2sc(nn12)-c1ccccn1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044809 (CHEMBL3311075) Show SMILES COc1ccc(Cc2nn3c(nnc3s2)-c2ccco2)cc1OC Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044795 (CHEMBL3310820) Show SMILES Cc1cccc(c1)-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044814 (CHEMBL3311070) Show SMILES C1Oc2ccccc2OC1c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044820 (CHEMBL3311174) Show SMILES C(Cc1nn2c(nnc2s1)-c1ccco1)Cc1ccccc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.22E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044821 (CHEMBL3311173) Show SMILES CCOc1ccccc1OCc1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044801 (CHEMBL3311081) Show SMILES Cc1ccccc1OCc1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.87E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044787 (CHEMBL3311066) Show SMILES C=CCOc1cccc(c1)-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.88E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM54959 (3-(2-furyl)-6-m-phenetyl-[1,2,4]triazolo[3,4-b][1,...) Show SMILES CCOc1cccc(c1)-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044793 (CHEMBL1339743) Show SMILES COc1cccc(c1)-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044786 (CHEMBL3311067) Show SMILES c1coc(c1)-c1nnc2sc(nn12)-c1cc2ccccc2o1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM40580 (3,6-Di-furan-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thi...) Show SMILES c1coc(c1)-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044790 (CHEMBL3311063) Show SMILES CCOc1ccccc1-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM38321 (6-(3,4-dimethoxyphenyl)-3-(2-furanyl)-[1,2,4]triaz...) Show SMILES COc1ccc(cc1OC)-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.48E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044796 (CHEMBL3310819) Show SMILES Cc1ccc(cc1)-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.74E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044819 (CHEMBL3310815) Show SMILES c1coc(c1)-c1nnc2sc(nn12)-c1ccccc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.76E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044800 (CHEMBL3311082) Show SMILES Cc1ccc(OCc2nn3c(nnc3s2)-c2ccco2)cc1C Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.87E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044803 (CHEMBL1455931) Show SMILES Cc1ccc(OCc2nn3c(nnc3s2)-c2ccco2)cc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044788 (CHEMBL3311065) Show SMILES C=CCOc1ccc(cc1)-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.95E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50425974 (CHEMBL2314699) Show SMILES Oc1cccc(c1)C(=O)c1coc2ccc(O)cc12 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged SIRT1 coding region (156-664) (unknown origin) expressed in Escherichia coli BL21(DE3) using 31.25 uM ac-RHKKac-...				Eur J Med Chem 60: 441-50 (2013) Article DOI: 10.1016/j.ejmech.2012.12.026 BindingDB Entry DOI: 10.7270/Q2WW7K0B
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044791 (CHEMBL3311062) Show SMILES CCOc1ccc(cc1)-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044792 (CHEMBL1869344) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044813 (CHEMBL3311071) Show SMILES C(c1nn2c(nnc2s1)-c1ccco1)c1ccccc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.79E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044815 (CHEMBL3311069) Show SMILES C1COc2cc(ccc2O1)-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.07E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044799 (CHEMBL1337712) Show SMILES COc1ccc(OCc2nn3c(nnc3s2)-c2ccco2)cc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50425972 (CHEMBL2314701) Show SMILES COc1ccc(O)cc1C(=O)c1coc2ccc(O)cc12 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged SIRT1 coding region (156-664) (unknown origin) expressed in Escherichia coli BL21(DE3) using 31.25 uM ac-RHKKac-...				Eur J Med Chem 60: 441-50 (2013) Article DOI: 10.1016/j.ejmech.2012.12.026 BindingDB Entry DOI: 10.7270/Q2WW7K0B
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044816 (CHEMBL1576457) Show SMILES c1coc(c1)-c1nnc2sc(nn12)-c1ccccn1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human SIRT1 F414A mutant expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate assessed as inhibit...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50425973 (CHEMBL2314700) Show SMILES COc1ccc(O)c(c1)C(=O)c1coc2ccc(O)cc12 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged SIRT1 coding region (156-664) (unknown origin) expressed in Escherichia coli BL21(DE3) using 31.25 uM ac-RHKKac-...				Eur J Med Chem 60: 441-50 (2013) Article DOI: 10.1016/j.ejmech.2012.12.026 BindingDB Entry DOI: 10.7270/Q2WW7K0B
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044785 (CHEMBL3311068) Show SMILES C1Oc2ccc(cc2O1)-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044794 (CHEMBL3310821) Show SMILES COc1ccc(cc1)-c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044807 (CHEMBL3311077) Show SMILES C(Cc1ccccc1)c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.74E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044823 (CHEMBL3311083) Show SMILES COc1cccc(OCc2nn3c(nnc3s2)-c2ccco2)c1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.84E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044818 (CHEMBL3310816) Show SMILES c1coc(c1)-c1nnc2sc(nn12)-c1ccncc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044822 (CHEMBL3311084) Show SMILES COc1ccccc1OCc1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044806 (CHEMBL1613321) Show SMILES C(Oc1ccccc1)c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044789 (CHEMBL3311064) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044798 (CHEMBL3310818) Show SMILES c1coc(c1)-c1nnc2sc(nn12)-c1cnccn1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.66E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044808 (CHEMBL3311076) Show SMILES C(c1nn2c(nnc2s1)-c1ccco1)c1ccc2OCCOc2c1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044805 (CHEMBL3311078) Show SMILES CC(Oc1ccccc1)c1nn2c(nnc2s1)-c1ccco1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.79E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50425975 (CHEMBL2314711) Show SMILES Oc1ccc2occ(C(=O)c3ccccc3O)c2c1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged SIRT1 coding region (156-664) (unknown origin) expressed in Escherichia coli BL21(DE3) using 31.25 uM ac-RHKKac-...				Eur J Med Chem 60: 441-50 (2013) Article DOI: 10.1016/j.ejmech.2012.12.026 BindingDB Entry DOI: 10.7270/Q2WW7K0B
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044802 (CHEMBL3311080) Show SMILES Cc1cccc(OCc2nn3c(nnc3s2)-c2ccco2)c1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044810 (CHEMBL3311074) Show SMILES COc1ccc(Cc2nn3c(nnc3s2)-c2ccco2)cc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.69E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044811 (CHEMBL3311073) Show SMILES Clc1ccc(Cc2nn3c(nnc3s2)-c2ccco2)cc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM50044817 (CHEMBL3310817) Show SMILES c1coc(c1)-c1nnc2sc(nn12)-c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.88E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of hexa-His-tagged recombinant human SIRT1 expressed in Escherichia coli BL21(DE3) using AMC-labeled Arg-His-Lys-Lys(ac) as substrate asse...				Bioorg Med Chem Lett 24: 3050-6 (2014) Article DOI: 10.1016/j.bmcl.2014.05.028 BindingDB Entry DOI: 10.7270/Q2MW2JSV
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair

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