| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-2 |
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| Ligand | BDBM50427000 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_939308 (CHEMBL2327273) |
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| IC50 | 2700±n/a nM |
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| Citation |  Geurink, PP; van der Linden, WA; Mirabella, AC; Gallastegui, N; de Bruin, G; Blom, AE; Voges, MJ; Mock, ED; Florea, BI; van der Marel, GA; Driessen, C; van der Stelt, M; Groll, M; Overkleeft, HS; Kisselev, AF Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites. J Med Chem56:1262-75 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-2 |
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| Name: | Proteasome subunit beta type-2 |
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| Synonyms: | 20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22837.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1294233 |
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| Residue: | 201 |
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| Sequence: | MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYI
QKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDY
LAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSV
RIIDKNGIHDLDNISFPKQGS
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| BDBM50427000 |
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| n/a |
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| Name | BDBM50427000 |
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| Synonyms: | CHEMBL2326265 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H45N7O5S |
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| Mol. Mass. | 639.809 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])\C=C\S(C)(=O)=O |r| |
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| Structure | 
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