| Reaction Details |
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 | Report a problem with these data |
| Target | D-amino-acid oxidase |
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| Ligand | BDBM50427008 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_939404 (CHEMBL2327670) |
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| IC50 | 75000±n/a nM |
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| Citation |  Inoue, T; Morita, M; Tojo, T; Yoshihara, K; Nagashima, A; Moritomo, A; Ohkubo, M; Miyake, H Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema. Bioorg Med Chem21:1219-33 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D-amino-acid oxidase |
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| Name: | D-amino-acid oxidase |
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| Synonyms: | D-Amino Acid Oxidase (DAAO) | DAMOX | Dao | Dao1 | OXDA_RAT |
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| Type: | Homodimer |
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| Mol. Mass.: | 38824.91 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Recombinant rat DAAO expressed and purified from sf9 insect cells, was used in enzyme assays. |
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| Residue: | 346 |
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| Sequence: | MRVAVIGAGVIGLSTALCIHERYHPAQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSN
PQEAEWNQQTFDHLQSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKSTVLGFRKLTPSE
LDMFPDYSYGWFNTSLLLEGKSYLSWLTERLTERGVKFIHRKVASFEEVVRGGVDVIINC
TGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGV
FQLGNWSELNSVHDHNTIWKSCCQLEPTLKNARIMGELTGFRPVRPQVRLERERLRFGSS
SAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKNLSRMPPSHL
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| BDBM50427008 |
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| n/a |
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| Name | BDBM50427008 |
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| Synonyms: | CHEMBL2326864 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17N5OS |
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| Mol. Mass. | 303.383 |
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| SMILES | [#6]-[#6](=O)-[#7]-c1nc(-[#6]-[#6]-c2ccc(cc2)\[#7]=[#6](\[#7])-[#7])cs1 |
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| Structure | 
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