Reaction Details |
| Report a problem with these data |
Target | Arginase-1 |
---|
Ligand | BDBM50427902 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_940979 (CHEMBL2330669) |
---|
IC50 | >300000±n/a nM |
---|
Citation | Van Zandt, MC; Whitehouse, DL; Golebiowski, A; Ji, MK; Zhang, M; Beckett, RP; Jagdmann, GE; Ryder, TR; Sheeler, R; Andreoli, M; Conway, B; Mahboubi, K; D'Angelo, G; Mitschler, A; Cousido-Siah, A; Ruiz, FX; Howard, EI; Podjarny, AD; Schroeter, H Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem56:2568-80 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Arginase-1 |
---|
Name: | Arginase-1 |
Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
Type: | PROTEIN |
Mol. Mass.: | 34737.53 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_978893 |
Residue: | 322 |
Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
|
|
|
BDBM50427902 |
---|
n/a |
---|
Name | BDBM50427902 |
Synonyms: | CHEMBL2326091 |
Type | Small organic molecule |
Emp. Form. | C13H27BN2O4 |
Mol. Mass. | 286.175 |
SMILES | N[C@@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O |r| |
Structure |
|