| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Liver carboxylesterase 1 |
|---|
| Ligand | BDBM51317 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_944083 (CHEMBL2341916) |
|---|
| Ki | 26250±n/a nM |
|---|
| Citation |  Hatfield, MJ; Tsurkan, LG; Hyatt, JL; Edwards, CC; Lemoff, A; Jeffries, C; Yan, B; Potter, PM Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen"). J Nat Prod76:36-44 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Liver carboxylesterase 1 |
|---|
| Name: | Liver carboxylesterase 1 |
|---|
| Synonyms: | Acyl coenzyme A:cholesterol acyltransferase | Acyl-CoA: cholesterol acyltransferase (ACAT) | CES1 | CES2 | EST1_HUMAN | SES1 | Serine hydrolase (CES1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 62520.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 567 |
|---|
| Sequence: | MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN
IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP
MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL
IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF
LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK
DKEVAFWTNLFAKKAVEKPPQTEHIEL
|
|
|
|---|
| BDBM51317 |
|---|
| n/a |
|---|
| Name | BDBM51317 |
|---|
| Synonyms: | 1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione | 1,6-dimethylnaphtho[1,2-g]benzofuran-10,11-dione | 1,6-dimethylnaphtho[1,2-g]benzofuran-10,11-quinone | MLS000697676 | SMR000445578 | TANSHINONE I | acs.jmedchem.1c00409_ST.675 | cid_114917 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H12O3 |
|---|
| Mol. Mass. | 276.2861 |
|---|
| SMILES | Cc1coc-2c1C(=O)C(=O)c1c-2ccc2c(C)cccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
