Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50468028 (CHEMBL4290236) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 0.328 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human CE1 using o-NPA as substrate | J Nat Prod 81: 2410-2418 (2018) Article DOI: 10.1021/acs.jnatprod.8b00378 BindingDB Entry DOI: 10.7270/Q2NC63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50468026 (CHEMBL4293626) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 0.417 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human CE1 using o-NPA as substrate | J Nat Prod 81: 2410-2418 (2018) Article DOI: 10.1021/acs.jnatprod.8b00378 BindingDB Entry DOI: 10.7270/Q2NC63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22859 (1,2-Dione-Based Compound, 16 | 1,2-dihydroaceanthr...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 5727-34 (2007) Article DOI: 10.1021/jm0706867 BindingDB Entry DOI: 10.7270/Q2Q52MWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50468029 (CHEMBL4282357) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human CE1 using o-NPA as substrate | J Nat Prod 81: 2410-2418 (2018) Article DOI: 10.1021/acs.jnatprod.8b00378 BindingDB Entry DOI: 10.7270/Q2NC63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22857 (1,2-Dione-Based Compound, 14 | 9,10-dihydrophenant...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 5727-34 (2007) Article DOI: 10.1021/jm0706867 BindingDB Entry DOI: 10.7270/Q2Q52MWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22857 (1,2-Dione-Based Compound, 14 | 9,10-dihydrophenant...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assay | J Nat Prod 76: 36-44 (2013) Article DOI: 10.1021/np300628a BindingDB Entry DOI: 10.7270/Q2VX0HWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50468027 (CHEMBL4285759) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human CE1 using o-NPA as substrate | J Nat Prod 81: 2410-2418 (2018) Article DOI: 10.1021/acs.jnatprod.8b00378 BindingDB Entry DOI: 10.7270/Q2NC63XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233201 (CHEMBL4101254) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrate | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233200 (CHEMBL4071772) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrate | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50350327 (CHEMBL1812857) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assay | J Nat Prod 76: 36-44 (2013) Article DOI: 10.1021/np300628a BindingDB Entry DOI: 10.7270/Q2VX0HWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233189 (CHEMBL4090451) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrate | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XII (Homo sapiens (Human)) | BDBM22850 (1,2-Dione-Based Compound, 7 | 1,2-dicyclohexyletha...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 5 | -47.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 5727-34 (2007) Article DOI: 10.1021/jm0706867 BindingDB Entry DOI: 10.7270/Q2Q52MWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XII (Homo sapiens (Human)) | BDBM22759 (1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5.60 | -47.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 5727-34 (2007) Article DOI: 10.1021/jm0706867 BindingDB Entry DOI: 10.7270/Q2Q52MWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Oryctolagus cuniculus (rabbit)) | BDBM22845 (1-{[4-({4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)me...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 1876-85 (2007) Article DOI: 10.1021/jm061471k BindingDB Entry DOI: 10.7270/Q2TX3CNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50350325 (CHEMBL1812863) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assay | J Nat Prod 76: 36-44 (2013) Article DOI: 10.1021/np300628a BindingDB Entry DOI: 10.7270/Q2VX0HWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50350328 (CHEMBL1812858) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assay | J Nat Prod 76: 36-44 (2013) Article DOI: 10.1021/np300628a BindingDB Entry DOI: 10.7270/Q2VX0HWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XII (Homo sapiens (Human)) | BDBM22859 (1,2-Dione-Based Compound, 16 | 1,2-dihydroaceanthr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 7.70 | -46.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 5727-34 (2007) Article DOI: 10.1021/jm0706867 BindingDB Entry DOI: 10.7270/Q2Q52MWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22759 (1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 5727-34 (2007) Article DOI: 10.1021/jm0706867 BindingDB Entry DOI: 10.7270/Q2Q52MWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22845 (1-{[4-({4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)me...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 1876-85 (2007) Article DOI: 10.1021/jm061471k BindingDB Entry DOI: 10.7270/Q2TX3CNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XII (Homo sapiens (Human)) | BDBM22842 (1-dodecyl-2,3-dihydro-1H-indole-2,3-dione | CHEMBL...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 1876-85 (2007) Article DOI: 10.1021/jm061471k BindingDB Entry DOI: 10.7270/Q2TX3CNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XII (Homo sapiens (Human)) | BDBM22845 (1-{[4-({4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)me...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 1876-85 (2007) Article DOI: 10.1021/jm061471k BindingDB Entry DOI: 10.7270/Q2TX3CNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22842 (1-dodecyl-2,3-dihydro-1H-indole-2,3-dione | CHEMBL...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 1876-85 (2007) Article DOI: 10.1021/jm061471k BindingDB Entry DOI: 10.7270/Q2TX3CNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XII (Homo sapiens (Human)) | BDBM22843 (1-hexadecyl-2,3-dihydro-1H-indole-2,3-dione | Isat...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 1876-85 (2007) Article DOI: 10.1021/jm061471k BindingDB Entry DOI: 10.7270/Q2TX3CNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233189 (CHEMBL4090451) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using o-nitrophenyl acetate as substrate monitored at 15 secs interval for... | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50458262 (CHEMBL4212576) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver carboxylesterase 1 using o-nitrophenyl acetate as substrate | Eur J Med Chem 149: 79-89 (2018) Article DOI: 10.1016/j.ejmech.2018.02.052 BindingDB Entry DOI: 10.7270/Q2K076WP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233194 (CHEMBL4087100) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrate | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50458275 (CHEMBL4204853) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver carboxylesterase 1 using o-nitrophenyl acetate as substrate | Eur J Med Chem 149: 79-89 (2018) Article DOI: 10.1016/j.ejmech.2018.02.052 BindingDB Entry DOI: 10.7270/Q2K076WP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233199 (CHEMBL4098780) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrate | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XII (Homo sapiens (Human)) | BDBM22722 (1,2-diphenylethane-1,2-dione | Benzil | CHEMBL1898...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 14.7 | -44.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 5727-34 (2007) Article DOI: 10.1021/jm0706867 BindingDB Entry DOI: 10.7270/Q2Q52MWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cocaine esterase (Homo sapiens (Human)) | BDBM22722 (1,2-diphenylethane-1,2-dione | Benzil | CHEMBL1898...) | NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human iCE using o-NPA as substrate by spectrophotometric assay | J Nat Prod 76: 36-44 (2013) Article DOI: 10.1021/np300628a BindingDB Entry DOI: 10.7270/Q2VX0HWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22858 (1,2-Dione-Based Compound, 15 | 2-nitro-9,10-dihydr...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 15.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 5727-34 (2007) Article DOI: 10.1021/jm0706867 BindingDB Entry DOI: 10.7270/Q2Q52MWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233191 (CHEMBL4095556) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using o-nitrophenyl acetate as substrate monitored at 15 secs interval for... | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22843 (1-hexadecyl-2,3-dihydro-1H-indole-2,3-dione | Isat...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 1876-85 (2007) Article DOI: 10.1021/jm061471k BindingDB Entry DOI: 10.7270/Q2TX3CNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233191 (CHEMBL4095556) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrate | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233196 (CHEMBL2391135) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrate | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233193 (CHEMBL4062476) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrate | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233198 (CHEMBL4082280) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using o-nitrophenyl acetate as substrate monitored at 15 secs interval for... | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233194 (CHEMBL4087100) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using o-nitrophenyl acetate as substrate monitored at 15 secs interval for... | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22793 (1‐phenylindole‐2,3‐dione (Compou...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 1876-85 (2007) Article DOI: 10.1021/jm061471k BindingDB Entry DOI: 10.7270/Q2TX3CNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cocaine esterase (Homo sapiens (Human)) | BDBM22734 (1,2-bis(3,5-difluorophenyl)ethane-1,2-dione | Benz...) | NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human iCE using o-NPA as substrate by spectrophotometric assay | J Nat Prod 76: 36-44 (2013) Article DOI: 10.1021/np300628a BindingDB Entry DOI: 10.7270/Q2VX0HWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22793 (1‐phenylindole‐2,3‐dione (Compou...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assay | J Nat Prod 76: 36-44 (2013) Article DOI: 10.1021/np300628a BindingDB Entry DOI: 10.7270/Q2VX0HWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50233195 (CHEMBL2391134) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using oseltamivir as substrate | J Med Chem 60: 1568-1579 (2017) Article DOI: 10.1021/acs.jmedchem.6b01849 BindingDB Entry DOI: 10.7270/Q2FF3VMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22795 (1-[(4-chlorophenyl)methyl]-2,3-dihydro-1H-indole-2...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 1876-85 (2007) Article DOI: 10.1021/jm061471k BindingDB Entry DOI: 10.7270/Q2TX3CNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22795 (1-[(4-chlorophenyl)methyl]-2,3-dihydro-1H-indole-2...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assay | J Nat Prod 76: 36-44 (2013) Article DOI: 10.1021/np300628a BindingDB Entry DOI: 10.7270/Q2VX0HWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50458274 (CHEMBL4206049) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver carboxylesterase 1 using o-nitrophenyl acetate as substrate | Eur J Med Chem 149: 79-89 (2018) Article DOI: 10.1016/j.ejmech.2018.02.052 BindingDB Entry DOI: 10.7270/Q2K076WP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50458261 (CHEMBL4211853) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human liver carboxylesterase 1 using o-nitrophenyl acetate as substrate | Eur J Med Chem 149: 79-89 (2018) Article DOI: 10.1016/j.ejmech.2018.02.052 BindingDB Entry DOI: 10.7270/Q2K076WP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cocaine esterase (Homo sapiens (Human)) | BDBM50350328 (CHEMBL1812858) | NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human iCE using o-NPA as substrate by spectrophotometric assay | J Nat Prod 76: 36-44 (2013) Article DOI: 10.1021/np300628a BindingDB Entry DOI: 10.7270/Q2VX0HWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM50350324 (CHEMBL1812862) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assay | J Nat Prod 76: 36-44 (2013) Article DOI: 10.1021/np300628a BindingDB Entry DOI: 10.7270/Q2VX0HWJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22853 (1,2-Dione-Based Compound, 10 | 1,2-dihydroacenapht...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 31 | -42.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 5727-34 (2007) Article DOI: 10.1021/jm0706867 BindingDB Entry DOI: 10.7270/Q2Q52MWQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM22796 (1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indo...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w... | J Med Chem 50: 1876-85 (2007) Article DOI: 10.1021/jm061471k BindingDB Entry DOI: 10.7270/Q2TX3CNK | |||||||||||
More data for this Ligand-Target Pair |
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