| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Liver carboxylesterase 1 |
|---|
| Ligand | BDBM22795 |
|---|
| Substrate/Competitor | BDBM22723 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| Ki | 25±n/a nM |
|---|
| Citation |  Hyatt, JL; Moak, T; Hatfield, MJ; Tsurkan, L; Edwards, CC; Wierdl, M; Danks, MK; Wadkins, RM; Potter, PM Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem50:1876-85 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Liver carboxylesterase 1 |
|---|
| Name: | Liver carboxylesterase 1 |
|---|
| Synonyms: | Acyl coenzyme A:cholesterol acyltransferase | Acyl-CoA: cholesterol acyltransferase (ACAT) | CES1 | CES2 | EST1_HUMAN | SES1 | Serine hydrolase (CES1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 62520.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 567 |
|---|
| Sequence: | MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN
IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP
MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL
IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF
LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK
DKEVAFWTNLFAKKAVEKPPQTEHIEL
|
|
|
|---|
| BDBM22795 |
|---|
| BDBM22723 |
|---|
| Name | BDBM22795 |
|---|
| Synonyms: | 1-[(4-chlorophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione | Isatin-based compound, 15 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H10ClNO2 |
|---|
| Mol. Mass. | 271.698 |
|---|
| SMILES | Clc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
