Reaction Details |
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Target | NAD-dependent protein deacetylase sirtuin-1 |
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Ligand | BDBM50431121 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_948318 (CHEMBL2341152) |
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IC50 | 5.3±n/a nM |
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Citation | Disch, JS; Evindar, G; Chiu, CH; Blum, CA; Dai, H; Jin, L; Schuman, E; Lind, KE; Belyanskaya, SL; Deng, J; Coppo, F; Aquilani, L; Graybill, TL; Cuozzo, JW; Lavu, S; Mao, C; Vlasuk, GP; Perni, RB Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem56:3666-79 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent protein deacetylase sirtuin-1 |
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Name: | NAD-dependent protein deacetylase sirtuin-1 |
Synonyms: | NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2 |
Type: | Developmental protein; hydrolase |
Mol. Mass.: | 81626.66 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 747 |
Sequence: | MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
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BDBM50431121 |
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n/a |
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Name | BDBM50431121 |
Synonyms: | CHEMBL2332037 |
Type | Small organic molecule |
Emp. Form. | C24H28N6O3S |
Mol. Mass. | 480.583 |
SMILES | CCNC(=O)c1cccc(c1)C(=O)NCCC1CCN(CC1)c1ncnc2cc(sc12)C(N)=O |
Structure |
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