| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lanosterol synthase ERG7 |
|---|
| Ligand | BDBM50433362 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_956105 (CHEMBL2379169) |
|---|
| IC50 | 1300±n/a nM |
|---|
| Citation |  Lange, S; Keller, M; Müller, C; Oliaro-Bosso, S; Balliano, G; Bracher, F Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors. Eur J Med Chem63:758-64 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lanosterol synthase ERG7 |
|---|
| Name: | Lanosterol synthase ERG7 |
|---|
| Synonyms: | ERG7 | ERG7_YEAST | Lanosterol synthase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 83460.43 |
|---|
| Organism: | Saccharomyces cerevisiae |
|---|
| Description: | ChEMBL_956105 |
|---|
| Residue: | 731 |
|---|
| Sequence: | MTEFYSDTIGLPKTDPRLWRLRTDELGRESWEYLTPQQAANDPPSTFTQWLLQDPKFPQP
HPERNKHSPDFSAFDACHNGASFFKLLQEPDSGIFPCQYKGPMFMTIGYVAVNYIAGIEI
PEHERIELIRYIVNTAHPVDGGWGLHSVDKSTVFGTVLNYVILRLLGLPKDHPVCAKARS
TLLRLGGAIGSPHWGKIWLSALNLYKWEGVNPAPPETWLLPYSLPMHPGRWWVHTRGVYI
PVSYLSLVKFSCPMTPLLEELRNEIYTKPFDKINFSKNRNTVCGVDLYYPHSTTLNIANS
LVVFYEKYLRNRFIYSLSKKKVYDLIKTELQNTDSLCIAPVNQAFCALVTLIEEGVDSEA
FQRLQYRFKDALFHGPQGMTIMGTNGVQTWDCAFAIQYFFVAGLAERPEFYNTIVSAYKF
LCHAQFDTECVPGSYRDKRKGAWGFSTKTQGYTVADCTAEAIKAIIMVKNSPVFSEVHHM
ISSERLFEGIDVLLNLQNIGSFEYGSFATYEKIKAPLAMETLNPAEVFGNIMVEYPYVEC
TDSSVLGLTYFHKYFDYRKEEIRTRIRIAIEFIKKSQLPDGSWYGSWGICFTYAGMFALE
ALHTVGETYENSSTVRKGCDFLVSKQMKDGGWGESMKSSELHSYVDSEKSLVVQTAWALI
ALLFAEYPNKEVIDRGIDLLKNRQEESGEWKFESVEGVFNHSCAIEYPSYRFLFPIKALG
MYSRAYETHTL
|
|
|
|---|
| BDBM50433362 |
|---|
| n/a |
|---|
| Name | BDBM50433362 |
|---|
| Synonyms: | CHEMBL2377451 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H43N |
|---|
| Mol. Mass. | 333.5942 |
|---|
| SMILES | CC(C)CCC[C@@H](C)[C@H]1CCC2=C(CCCN(C)C)CCC[C@]12C |r,c:11| |
|---|
| Structure | 
|
|---|
Search and Browse
