Ki Summary

Reaction Details

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Target

Hepatocyte growth factor receptor

Ligand

BDBM50434711

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_961885 (CHEMBL2390327)

IC50

5.9±n/a nM

Citation

Li, S; Zhao, Y; Wang, K; Gao, Y; Han, J; Cui, B; Gong, P Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitors. Bioorg Med Chem21:2843-55 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Hepatocyte growth factor receptor

Name:

Hepatocyte growth factor receptor

Synonyms:

Type:

Protein

Mol. Mass.:

155559.73

Organism:

Homo sapiens (Human)

Description:

P08581

Residue:

1390

Sequence:

MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEH
HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL
VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE
FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL
TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF
TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL
LDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK
TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVIT
SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVH
EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPV
FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQ
IKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGS
CRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVL
SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF
VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD
TRPASFWETS

BDBM50434711

n/a

Name

BDBM50434711

Synonyms:

CHEMBL2385193

Type

Small organic molecule

Emp. Form.

C40H36Cl2FN5O5

Mol. Mass.

756.649

SMILES

COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5c(Cl)cccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 |(48.04,-29.9,;48.04,-31.44,;49.37,-32.21,;50.7,-31.44,;52.04,-32.21,;53.36,-31.43,;53.36,-29.89,;54.68,-29.12,;56.01,-29.88,;57.34,-29.11,;57.33,-27.57,;58.66,-26.79,;60,-27.55,;60.01,-29.09,;61.33,-26.77,;61.32,-25.24,;62.66,-24.46,;62.66,-22.92,;61.32,-22.16,;60,-22.94,;61.31,-20.64,;62.65,-19.85,;64,-20.59,;63.99,-22.13,;65.33,-22.9,;63.99,-25.23,;65.32,-24.44,;66.66,-25.21,;66.67,-26.77,;65.33,-27.54,;63.99,-26.77,;62.67,-27.54,;62.68,-29.08,;55.99,-26.8,;54.66,-27.59,;53.32,-26.83,;54.7,-32.19,;54.71,-33.74,;53.37,-34.52,;52.04,-33.75,;50.71,-34.53,;49.37,-33.76,;48.04,-34.53,;46.7,-33.75,;45.37,-34.52,;44.04,-33.75,;44.04,-32.21,;45.37,-31.44,;45.38,-29.91,;44.05,-29.13,;44.06,-27.59,;42.71,-29.9,;42.7,-31.44,)|

Structure