Ki Summary

Reaction Details

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Target

Hepatocyte growth factor receptor

Ligand

BDBM50434712

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_961885 (CHEMBL2390327)

IC50

5.2±n/a nM

Citation

Li, S; Zhao, Y; Wang, K; Gao, Y; Han, J; Cui, B; Gong, P Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitors. Bioorg Med Chem21:2843-55 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Hepatocyte growth factor receptor

Name:

Hepatocyte growth factor receptor

Synonyms:

Type:

Protein

Mol. Mass.:

155559.73

Organism:

Homo sapiens (Human)

Description:

P08581

Residue:

1390

Sequence:

MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEH
HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL
VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE
FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL
TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF
TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL
LDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK
TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVIT
SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVH
EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPV
FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQ
IKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGS
CRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVL
SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF
VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD
TRPASFWETS

BDBM50434712

n/a

Name

BDBM50434712

Synonyms:

CHEMBL2385186

Type

Small organic molecule

Emp. Form.

C39H34Cl2FN5O5

Mol. Mass.

742.622

SMILES

COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5c(Cl)cccc5Cl)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCCC1 |(22.57,-52.86,;22.57,-54.4,;23.9,-55.17,;25.23,-54.4,;26.57,-55.16,;27.89,-54.39,;27.89,-52.85,;29.21,-52.07,;30.54,-52.84,;31.87,-52.07,;31.86,-50.52,;33.19,-49.75,;34.53,-50.51,;34.54,-52.05,;35.86,-49.73,;35.85,-48.19,;37.19,-47.42,;37.19,-45.88,;38.52,-45.09,;39.85,-45.86,;38.53,-43.55,;37.18,-42.81,;35.84,-43.59,;35.85,-45.12,;34.53,-45.9,;38.52,-48.18,;39.85,-47.4,;41.19,-48.17,;41.19,-49.73,;39.86,-50.5,;38.52,-49.73,;37.2,-50.5,;37.21,-52.04,;30.52,-49.76,;29.19,-50.54,;27.85,-49.79,;29.23,-55.15,;29.24,-56.7,;27.9,-57.47,;26.57,-56.71,;25.24,-57.48,;23.9,-56.71,;22.57,-57.48,;21.23,-56.71,;19.9,-57.48,;18.57,-56.71,;18.57,-55.17,;19.9,-54.4,;19.91,-52.87,;18.58,-52.09,;17.24,-52.86,;17.23,-54.4,)|

Structure