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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bifunctional epoxide hydrolase 2 | ||
| Ligand | BDBM50435135 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_963496 (CHEMBL2394377) | ||
| IC50 | 2463±n/a nM | ||
| Citation |  North, EJ; Scherman, MS; Bruhn, DF; Scarborough, JS; Maddox, MM; Jones, V; Grzegorzewicz, A; Yang, L; Hess, T; Morisseau, C; Jackson, M; McNeil, MR; Lee, RE Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties. Bioorg Med Chem21:2587-99 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bifunctional epoxide hydrolase 2 | |||
| Name: | Bifunctional epoxide hydrolase 2 | ||
| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 62613.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34913 | ||
| Residue: | 555 | ||
| Sequence: |
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| BDBM50435135 | |||
| n/a | |||
| Name | BDBM50435135 | ||
| Synonyms: | CHEMBL2392740 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H26N4O | ||
| Mol. Mass. | 302.4145 | ||
| SMILES | CCn1nc(NC(=O)NC2C3CC4CC(C3)CC2C4)cc1C |TLB:8:9:11:15.14.13,THB:9:10:13:18.17.16,9:17:11.10.15:13,16:17:11:15.14.13,16:14:11:18.9.17,(14.16,-17.48,;12.65,-17.82,;12.19,-19.28,;10.73,-19.77,;10.74,-21.32,;9.41,-22.1,;8.08,-21.33,;8.08,-19.79,;6.74,-22.1,;5.41,-21.32,;4.92,-22.75,;5.41,-24.23,;4.08,-23.09,;2.6,-23.18,;2.05,-21.85,;3.34,-22.83,;2.56,-20.43,;4.09,-20.37,;4.5,-21.74,;12.21,-21.78,;13.1,-20.52,;14.64,-20.51,)| | ||
| Structure | 
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