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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bifunctional epoxide hydrolase 2 | ||
| Ligand | BDBM50435137 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_963496 (CHEMBL2394377) | ||
| IC50 | 2408±n/a nM | ||
| Citation |  North, EJ; Scherman, MS; Bruhn, DF; Scarborough, JS; Maddox, MM; Jones, V; Grzegorzewicz, A; Yang, L; Hess, T; Morisseau, C; Jackson, M; McNeil, MR; Lee, RE Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties. Bioorg Med Chem21:2587-99 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bifunctional epoxide hydrolase 2 | |||
| Name: | Bifunctional epoxide hydrolase 2 | ||
| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 62613.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34913 | ||
| Residue: | 555 | ||
| Sequence: |
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| BDBM50435137 | |||
| n/a | |||
| Name | BDBM50435137 | ||
| Synonyms: | CHEMBL2392738 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H22N4O2 | ||
| Mol. Mass. | 302.3715 | ||
| SMILES | O=C(NC1C2CC3CC(C2)CC1C3)Nc1nnc(o1)C1CC1 |TLB:2:3:5:9.8.7,THB:3:4:7:12.11.10,3:11:5.4.9:7,10:11:5:9.8.7,10:8:5:12.3.11,(21.06,-10.56,;21.06,-12.1,;19.73,-12.87,;18.4,-12.09,;17.9,-13.52,;18.39,-15,;17.06,-13.87,;15.58,-13.95,;15.03,-12.63,;16.32,-13.61,;15.54,-11.21,;17.07,-11.14,;17.49,-12.52,;22.39,-12.87,;23.72,-12.09,;25.19,-12.55,;26.08,-11.3,;25.17,-10.06,;23.71,-10.55,;25.63,-8.59,;26.76,-7.55,;25.29,-7.09,)| | ||
| Structure | 
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