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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bifunctional epoxide hydrolase 2 | ||
| Ligand | BDBM50435141 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_963496 (CHEMBL2394377) | ||
| IC50 | 73±n/a nM | ||
| Citation |  North, EJ; Scherman, MS; Bruhn, DF; Scarborough, JS; Maddox, MM; Jones, V; Grzegorzewicz, A; Yang, L; Hess, T; Morisseau, C; Jackson, M; McNeil, MR; Lee, RE Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties. Bioorg Med Chem21:2587-99 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bifunctional epoxide hydrolase 2 | |||
| Name: | Bifunctional epoxide hydrolase 2 | ||
| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 62613.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34913 | ||
| Residue: | 555 | ||
| Sequence: |
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| BDBM50435141 | |||
| n/a | |||
| Name | BDBM50435141 | ||
| Synonyms: | CHEMBL2392734 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H27N3O2 | ||
| Mol. Mass. | 317.4259 | ||
| SMILES | CC(C)(C)c1cc(NC(=O)NC2C3CC4CC(C3)CC2C4)no1 |TLB:10:11:13:17.16.15,THB:11:12:15:20.19.18,11:19:13.12.17:15,18:19:13:17.16.15,18:16:13:20.11.19,(13.67,-2.85,;12.16,-3.19,;11.12,-2.06,;12.55,-1.69,;11.7,-4.65,;10.24,-5.14,;10.25,-6.69,;8.92,-7.47,;7.59,-6.7,;7.59,-5.16,;6.25,-7.47,;4.92,-6.69,;4.43,-8.12,;4.92,-9.6,;3.59,-8.46,;2.11,-8.55,;1.56,-7.22,;2.85,-8.2,;2.07,-5.8,;3.6,-5.74,;4.01,-7.11,;11.72,-7.15,;12.61,-5.89,)| | ||
| Structure | 
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