| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A3 |
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| Ligand | BDBM21221 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_970296 (CHEMBL2403962) |
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| EC50 | 0.150000±n/a nM |
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| Citation |  Paoletta, S; Tosh, DK; Finley, A; Gizewski, ET; Moss, SM; Gao, ZG; Auchampach, JA; Salvemini, D; Jacobson, KA Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain. J Med Chem56:5949-63 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A3 |
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| Name: | Adenosine receptor A3 |
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| Synonyms: | A3AR | AA3R_MOUSE | Adenosine A3 receptor | Adora3 | Gpcr2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36460.91 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1515686 |
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| Residue: | 319 |
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| Sequence: | MEADNTTETDWLNITYITMEAAIGLCAVVGNMLVIWVVKLNPTLRTTTVYFIVSLALADI
AVGVLVIPLAIAVSLQVKMHFYACLFMSCVLLIFTHASIMSLLAIAVHRYLRVKLTVRYR
TVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKATLASSQNSSTLLCHFRSVVSLDYMVF
FSFITWILVPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLF
ALCWLPLSIINFVSYFDVKIPDVAMCLGILLSHANSMMNPIVYACKIKKFKETYFLILRA
VRLCQTSDSLDSNMEQTTE
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| BDBM21221 |
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| n/a |
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| Name | BDBM21221 |
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| Synonyms: | (2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl]amino}-9H-purin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide | 2-Cl-IB-MECA | 2-chloro-N6-(3-iodobenzyl)adenosine-5-N-methylcarboxamide | C-IBzA-MU | C1-IB-MECA | CHEMBL431733 | CI-IB-MECA | Cl-IB-MECA | US20230364057, Compound 76 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18ClIN6O4 |
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| Mol. Mass. | 544.731 |
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| SMILES | CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12 |
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| Structure | 
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