| Reaction Details |
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 | Report a problem with these data |
| Target | Acidic mammalian chitinase |
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| Ligand | BDBM50438378 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_976716 (CHEMBL2417154) |
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| IC50 | 4000±n/a nM |
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| Citation |  Wakasugi, M; Gouda, H; Hirose, T; Sugawara, A; Yamamoto, T; Shiomi, K; Sunazuka, T; Omura, S; Hirono, S Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening. Bioorg Med Chem21:3214-20 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acidic mammalian chitinase |
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| Name: | Acidic mammalian chitinase |
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| Synonyms: | AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902 |
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| Type: | Protein |
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| Mol. Mass.: | 52266.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BZP6 |
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| Residue: | 476 |
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| Sequence: | MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG
RQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFI
TSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMV
TAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAY
LNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGI
WAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVW
AIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSS
GGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
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| BDBM50438378 |
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| n/a |
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| Name | BDBM50438378 |
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| Synonyms: | CHEMBL2413400 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N5O2S |
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| Mol. Mass. | 383.467 |
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| SMILES | CN(C)c1ccc(C=C(NC(=O)c2ccccc2)C(=O)NNC(N)=S)cc1 |w:7.6| |
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| Structure | 
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