Reaction Details |
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Target | P2Y purinoceptor 12 |
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Ligand | BDBM50439271 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_980723 (CHEMBL2424010) |
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IC50 | 480±n/a nM |
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Citation | Bach, P; Antonsson, T; Bylund, R; Björkman, JA; Österlund, K; Giordanetto, F; van Giezen, JJ; Andersen, SM; Zachrisson, H; Zetterberg, F Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J Med Chem56:7015-24 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2Y purinoceptor 12 |
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Name: | P2Y purinoceptor 12 |
Synonyms: | ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999 |
Type: | Enzyme |
Mol. Mass.: | 39458.48 |
Organism: | Homo sapiens (Human) |
Description: | Q9H244 |
Residue: | 342 |
Sequence: | MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFI
IFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITI
DRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKS
EFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFI
IIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFF
LCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
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BDBM50439271 |
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n/a |
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Name | BDBM50439271 |
Synonyms: | CHEMBL2419496 |
Type | Small organic molecule |
Emp. Form. | C16H15Cl2N3O5S2 |
Mol. Mass. | 464.343 |
SMILES | CCOC(=O)c1cnc(N2CC(C2)C(=O)NS(=O)(=O)c2ccc(Cl)s2)c(Cl)c1 |
Structure |
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