| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Disintegrin and metalloproteinase domain-containing protein 17 |
|---|
| Ligand | BDBM50131516 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_984240 (CHEMBL2432518) |
|---|
| IC50 | 17±n/a nM |
|---|
| Citation |  Nuti, E; Casalini, F; Santamaria, S; Fabbi, M; Carbotti, G; Ferrini, S; Marinelli, L; La Pietra, V; Novellino, E; Camodeca, C; Orlandini, E; Nencetti, S; Rossello, A Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models. J Med Chem56:8089-103 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Disintegrin and metalloproteinase domain-containing protein 17 |
|---|
| Name: | Disintegrin and metalloproteinase domain-containing protein 17 |
|---|
| Synonyms: | ADA17_HUMAN | ADAM17 | CSVP | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM-17) | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) | TACE | TNF-alpha convertase | TNF-alpha converting enzyme (TACE) | TNF-alpha-converting enzyme (TACE) | Tumor Necrosis Factor Alpha Converting Enzyme | Tumor necrosis factor-α converting enzyme (TACE) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 93007.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | |
|---|
| Residue: | 824 |
|---|
| Sequence: | MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL
QTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVV
GEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMG
RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNM
AKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSC
KVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS
INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMD
SASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKD
PFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
|
|
|
|---|
| BDBM50131516 |
|---|
| n/a |
|---|
| Name | BDBM50131516 |
|---|
| Synonyms: | 2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyacetamide | 2-(4-But-2-ynyloxy-benzenesulfonylamino)-N-hydroxy-acetamide | CHEMBL94715 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H14N2O5S |
|---|
| Mol. Mass. | 298.315 |
|---|
| SMILES | CC#CCOc1ccc(cc1)S(=O)(=O)NCC(=O)NO |
|---|
| Structure | 
|
|---|
Search and Browse
