| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50441718 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_988271 (CHEMBL2439725) |
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| IC50 | >26000±n/a nM |
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| Citation |  Skerlj, R; Bridger, G; Zhou, Y; Bourque, E; McEachern, E; Metz, M; Harwig, C; Li, TS; Yang, W; Bogucki, D; Zhu, Y; Langille, J; Veale, D; Ba, T; Bey, M; Baird, I; Kaller, A; Krumpak, M; Leitch, D; Satori, M; Vocadlo, K; Guay, D; Nan, S; Yee, H; Crawford, J; Chen, G; Wilson, T; Carpenter, B; Gauthier, D; Macfarland, R; Mosi, R; Bodart, V; Wong, R; Fricker, S; Schols, D Design of substituted imidazolidinylpiperidinylbenzoic acids as chemokine receptor 5 antagonists: potent inhibitors of R5 HIV-1 replication. J Med Chem56:8049-65 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50441718 |
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| n/a |
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| Name | BDBM50441718 |
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| Synonyms: | CHEMBL2435858 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H39N5O4 |
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| Mol. Mass. | 569.6939 |
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| SMILES | Cc1nc(Oc2ccc(cc2)C(N)=O)ccc1CN1CCC(CC1)N1[C@@H](CN(C2CCOCC2)C1=O)c1ccccc1 |r| |
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| Structure | 
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