Reaction Details |
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Target | Neuropeptide Y receptor type 4 |
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Ligand | BDBM50441958 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_992059 (CHEMBL2447702) |
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Ki | 509±n/a nM |
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Citation | Berlicki, L; Kaske, M; Gutièrrez-Abad, R; Bernhardt, G; Illa, O; Ortuno, RM; Cabrele, C; Buschauer, A; Reiser, O Replacement of Thr32 and Gln34 in the C-terminal neuropeptide Y fragment 25-36 by cis-cyclobutane and cis-cyclopentane β-amino acids shifts selectivity toward the Y(4) receptor. J Med Chem56:8422-31 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neuropeptide Y receptor type 4 |
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Name: | Neuropeptide Y receptor type 4 |
Synonyms: | NPY-Y4 | NPY4-R | NPY4R | NPY4R_HUMAN | PP1 | PPYR1 | Pancreatic polypeptide receptor 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 42207.58 |
Organism: | Homo sapiens (Human) |
Description: | NPY-Y4 PPYR1 HUMAN::P50391 |
Residue: | 375 |
Sequence: | MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNL
CLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFI
QCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSIL
ENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRR
LQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHG
NLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTE
VSKGSLRLSGRSNPI
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BDBM50441958 |
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n/a |
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Name | BDBM50441958 |
Synonyms: | CHEMBL2440119 |
Type | Small organic molecule |
Emp. Form. | C33H54N12O8 |
Mol. Mass. | 746.8575 |
SMILES | C[C@@H](O)[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| |
Structure |
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