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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Transient receptor potential cation channel subfamily V member 1 | ||
| Ligand | BDBM50442377 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_991132 (CHEMBL2446588) | ||
| IC50 | 180±n/a nM | ||
| Citation |  Ha, TH; Ryu, H; Kim, SE; Kim, HS; Ann, J; Tran, PT; Hoang, VH; Son, K; Cui, M; Choi, S; Blumberg, PM; Frank, R; Bahrenberg, G; Schiene, K; Christoph, T; Frormann, S; Lee, J TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides. Bioorg Med Chem21:6657-64 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Transient receptor potential cation channel subfamily V member 1 | |||
| Name: | Transient receptor potential cation channel subfamily V member 1 | ||
| Synonyms: | Capsaicin receptor | OTRPC1 | Osm-9-like TRP channel 1 | TRPV1 | TRPV1_HUMAN | Transient receptor potential cation channel subfamily V member 1 | Transient receptor potential cation channel subfamily V member 1 (TRPV1) | Transient receptor potential cation channel subfamily V member 1 (VR1/TRPV1) | Transient receptor potential cation channel subfamily V member 1(TRPV1) | VR1 | Vanilloid VR1 | Vanilloid receptor | Vanilloid receptor 1 | Vanilloid receptor 1 (TrpV1/Vr1) | Vanilloid receptor 1 (VRI/TRPV1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 94960.75 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q8NER1 | ||
| Residue: | 839 | ||
| Sequence: |
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| BDBM50442377 | |||
| n/a | |||
| Name | BDBM50442377 | ||
| Synonyms: | CHEMBL2442916 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H29F4N3O3S2 | ||
| Mol. Mass. | 547.629 | ||
| SMILES | CC(C(=O)NCc1ccc(nc1SC1CCC(C)CC1)C(F)(F)F)c1ccc(NS(C)(=O)=O)c(F)c1 |(23.62,-43.51,;23.62,-45.06,;22.29,-45.83,;20.95,-45.06,;22.29,-47.37,;20.95,-48.14,;19.61,-47.37,;19.61,-45.83,;18.28,-45.06,;16.95,-45.83,;16.95,-47.37,;18.28,-48.14,;18.28,-49.69,;16.95,-50.46,;15.62,-49.68,;14.3,-50.45,;14.29,-51.98,;12.95,-52.75,;15.62,-52.76,;16.96,-51.99,;15.6,-45.06,;15.6,-43.52,;14.27,-45.83,;14.27,-44.28,;24.96,-45.83,;24.96,-47.37,;26.29,-48.14,;27.64,-47.37,;28.96,-48.14,;28.97,-49.68,;27.64,-50.46,;29.74,-51.01,;30.51,-49.68,;27.64,-45.83,;28.97,-45.06,;26.29,-45.06,)| | ||
| Structure | 
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