Reaction Details |
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Target | Histamine receptor H3 |
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Ligand | BDBM50442631 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_990753 (CHEMBL2443820) |
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Ki | 6.8±n/a nM |
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Citation | Gao, Z; Hurst, WJ; Czechtizky, W; Francon, D; Griebel, G; Nagorny, R; Pichat, P; Schwink, L; Stengelin, S; Hendrix, JA; George, PG Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleep-wake disorders. Bioorg Med Chem Lett23:6141-5 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine receptor H3 |
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Name: | Histamine receptor H3 |
Synonyms: | n/a |
Type: | Enzyme |
Mol. Mass.: | 48611.84 |
Organism: | Macaca mulatta (Rhesus macaque) |
Description: | Q865E1 |
Residue: | 445 |
Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAG
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEQCWK
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BDBM50442631 |
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n/a |
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Name | BDBM50442631 |
Synonyms: | CHEMBL2441637 |
Type | Small organic molecule |
Emp. Form. | C22H33N3O2 |
Mol. Mass. | 371.5163 |
SMILES | C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(NC(=O)C2CCOCC2)c(C)c1 |r| |
Structure |
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