| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 1 |
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| Ligand | BDBM50442838 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_990216 (CHEMBL2444933) |
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| IC50 | 26±n/a nM |
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| Citation |  Kim, HM; Smith, MD; Kim, JH; Caplen, MA; Chan, TY; McKittrick, BA; Cook, JA; van Heek, M; Lachowicz, J Identification of 2-aminooxazole amides as acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) inhibitors through scaffold hopping strategy. Bioorg Med Chem Lett23:6410-4 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 1 |
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| Name: | Diacylglycerol O-acyltransferase 1 |
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| Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
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| Type: | Enzyme |
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| Mol. Mass.: | 56810.61 |
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| Organism: | Mus musculus (mouse) |
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| Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. |
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| Residue: | 498 |
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| Sequence: | MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVRDAAVSPDLGAGGDAPAPAPAPAHTR
DKDGRTSVGDGYWDLRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKY
GILVDPIQVVSLFLKDPYSWPAPCVIIASNIFVVAAFQIEKRLAVGALTEQMGLLLHVVN
LATIICFPAAVALLVESITPVGSVFALASYSIMFLKLYSYRDVNLWCRQRRVKAKAVSTG
KKVSGAAAQQAVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFT
QLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWFFHSCLNAV
AELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRHGSSKWVARTGVFL
TSAFFHEYLVSVPLRMFRLWAFTAMMAQVPLAWIVGRFFQGNYGNAAVWVTLIIGQPVAV
LMYVHDYYVLNYDAPVGV
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| BDBM50442838 |
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| n/a |
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| Name | BDBM50442838 |
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| Synonyms: | CHEMBL2441208 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27ClF3N7O3 |
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| Mol. Mass. | 577.986 |
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| SMILES | FC(F)(F)c1nc(oc1C(=O)Nc1ccc(nc1)N1CCN(CC1)C(=O)Nc1ccccc1Cl)N1CCCCC1 |
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| Structure | 
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