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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50444252 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1277932 (CHEMBL3094776) | ||
| IC50 | 13±n/a nM | ||
| Citation |  Zhang, W; McIver, AL; Stashko, MA; DeRyckere, D; Branchford, BR; Hunter, D; Kireev, D; Miley, MJ; Norris-Drouin, J; Stewart, WM; Lee, M; Sather, S; Zhou, Y; Di Paola, JA; Machius, M; Janzen, WP; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem56:9693-700 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
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| BDBM50444252 | |||
| n/a | |||
| Name | BDBM50444252 | ||
| Synonyms: | CHEMBL3093649 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H33N5O3 | ||
| Mol. Mass. | 391.5077 | ||
| SMILES | CCCCNc1ncc(C(=O)NC2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 |r,wU:20.20,wD:23.24,(39.42,-35.6,;40.75,-34.83,;42.08,-35.6,;43.42,-34.83,;44.75,-35.6,;46.08,-34.83,;47.42,-35.6,;48.76,-34.83,;48.75,-33.28,;50.08,-32.51,;50.08,-30.97,;51.42,-33.27,;52.75,-32.5,;54.08,-33.27,;55.41,-32.5,;55.41,-30.96,;54.07,-30.19,;52.74,-30.96,;47.41,-32.52,;47.41,-30.98,;46.07,-30.21,;44.74,-30.99,;43.4,-30.22,;43.4,-28.67,;42.07,-27.9,;44.74,-27.91,;46.07,-28.67,;46.09,-33.29,)| | ||
| Structure | 
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