| Reaction Details |
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 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
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| Ligand | BDBM50445729 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1284540 (CHEMBL3106735) |
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| IC50 | 121±n/a nM |
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| Citation |  Sun, S; Zhang, Z; Raina, V; Pokrovskaia, N; Hou, D; Namdari, R; Khakh, K; Ratkay, LG; McLaren, DG; Mork, M; Fu, J; Ferreira, S; Hubbard, B; Winther, MD; Dales, N Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects. Bioorg Med Chem Lett24:526-31 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stearoyl-CoA desaturase |
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| Name: | Stearoyl-CoA desaturase |
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| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41537.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00767 |
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| Residue: | 359 |
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| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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| BDBM50445729 |
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| n/a |
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| Name | BDBM50445729 |
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| Synonyms: | CHEMBL3104408 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16FN3O3S |
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| Mol. Mass. | 373.401 |
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| SMILES | Cc1nc(sc1C(=O)NCCc1ccc(F)cc1)-n1ccc(O)cc1=O |
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| Structure | 
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