| Reaction Details |
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 | Report a problem with these data |
| Target | Aldehyde dehydrogenase, mitochondrial |
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| Ligand | BDBM50133625 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1295317 (CHEMBL3130565) |
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| IC50 | 2100±n/a nM |
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| Citation |  Kimble-Hill, AC; Parajuli, B; Chen, CH; Mochly-Rosen, D; Hurley, TD Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. J Med Chem57:714-22 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldehyde dehydrogenase, mitochondrial |
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| Name: | Aldehyde dehydrogenase, mitochondrial |
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| Synonyms: | ALDH class 2 | ALDH-E2 | ALDH2 | ALDH2_HUMAN | ALDHI | ALDM | Aldehyde dehydrogenase (ALDH2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56382.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05091 |
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| Residue: | 517 |
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| Sequence: | MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
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| BDBM50133625 |
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| n/a |
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| Name | BDBM50133625 |
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| Synonyms: | 1-Benzyl-5-chloro-1H-indole-2,3-dione | CHEMBL336693 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10ClNO2 |
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| Mol. Mass. | 271.698 |
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| SMILES | Clc1ccc2N(Cc3ccccc3)C(=O)C(=O)c2c1 |
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| Structure | 
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