| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C epsilon type |
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| Ligand | BDBM50012921 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1352186 (CHEMBL3268159) |
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| IC50 | 25500±n/a nM |
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| Citation |  Rechfeld, F; Gruber, P; Kirchmair, J; Boehler, M; Hauser, N; Hechenberger, G; Garczarczyk, D; Lapa, GB; Preobrazhenskaya, MN; Goekjian, P; Langer, T; Hofmann, J Thienoquinolines as novel disruptors of the PKCe/RACK2 protein-protein interaction. J Med Chem57:3235-46 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C epsilon type |
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| Name: | Protein kinase C epsilon type |
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| Synonyms: | KPCE_HUMAN | PKC epsilon | PKCE | PRKCE | Protein kinase C epsilon | Protein kinase C epsilon type | Protein kinase C, PKC; classical/novel | Protein kinase C, epsilon | nPKC-epsilon |
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| Type: | Enzyme |
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| Mol. Mass.: | 83680.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
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| Residue: | 737 |
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| Sequence: | MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT
NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE
PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP
TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN
MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA
KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE
NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG
KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD
RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL
DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM
MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED
AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI
NQEEFKGFSYFGEDLMP
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| BDBM50012921 |
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| n/a |
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| Name | BDBM50012921 |
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| Synonyms: | CHEMBL3261337 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18N4O3S2 |
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| Mol. Mass. | 450.533 |
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| SMILES | CCOc1ccc2nc(NC(=O)c3sc4nc5cc(OC)ccc5cc4c3N)sc2c1 |
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| Structure | 
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