| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily A member 5 |
|---|
| Ligand | BDBM50016299 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1348919 (CHEMBL3271550) |
|---|
| IC50 | 1520±n/a nM |
|---|
| Citation |  Guo, X; Ma, X; Yang, Q; Xu, J; Huang, L; Jia, J; Shan, J; Liu, L; Chen, W; Chu, H; Wei, J; Zhang, X; Sun, H; Tang, Y; You, Q Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I). Eur J Med Chem81:89-94 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Potassium voltage-gated channel subfamily A member 5 |
|---|
| Name: | Potassium voltage-gated channel subfamily A member 5 |
|---|
| Synonyms: | HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 67222.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22460 |
|---|
| Residue: | 613 |
|---|
| Sequence: | MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA
DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ
RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ
SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF
EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG
SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII
DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL
QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT
VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG
TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL
YALCLDTSRETDL
|
|
|
|---|
| BDBM50016299 |
|---|
| n/a |
|---|
| Name | BDBM50016299 |
|---|
| Synonyms: | CHEMBL3262798 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H22N2O2S |
|---|
| Mol. Mass. | 330.444 |
|---|
| SMILES | Cc1ccc(OCCN2CCN(CC2)C(=O)c2cccs2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
