Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50020051 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1363772 (CHEMBL3294189) | ||
IC50 | 34±n/a nM | ||
Citation | Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Enzyme | ||
Mol. Mass.: | 56810.61 | ||
Organism: | Mus musculus (mouse) | ||
Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
Residue: | 498 | ||
Sequence: |
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BDBM50020051 | |||
n/a | |||
Name | BDBM50020051 | ||
Synonyms: | CHEMBL3287874 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H34N2O5 | ||
Mol. Mass. | 514.6121 | ||
SMILES | CCOc1ccc(NC(=O)N2CCOc3cc(ccc23)-c2ccc(cc2)[C@H]2CC[C@H](CC(O)=O)CC2)cc1 |r,wU:29.32,wD:26.28,(-1.18,-9.52,;.15,-10.29,;1.49,-9.52,;2.82,-10.29,;2.82,-11.83,;4.16,-12.6,;5.49,-11.83,;6.82,-12.6,;8.16,-11.83,;8.16,-10.29,;9.49,-12.6,;9.49,-14.14,;10.82,-14.91,;12.16,-14.14,;12.16,-12.6,;13.49,-11.83,;13.49,-10.29,;12.16,-9.52,;10.82,-10.29,;10.82,-11.83,;14.82,-9.52,;16.16,-10.29,;17.49,-9.52,;17.49,-7.98,;16.16,-7.21,;14.82,-7.98,;18.83,-7.21,;20.16,-7.98,;21.49,-7.21,;21.49,-5.67,;22.83,-4.9,;24.16,-5.67,;25.49,-4.9,;24.16,-7.21,;20.16,-4.9,;18.83,-5.67,;5.49,-10.29,;4.16,-9.52,)| | ||
Structure |