Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H3 receptor (GUINEA PIG) | BDBM50325449 (1-(2-(piperidin-1-yl)ethyl)-3-(1-(1-(pyridin-4-ylm...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brain | Bioorg Med Chem Lett 20: 5004-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.052 BindingDB Entry DOI: 10.7270/Q2N016QS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM303246 (2-amino-N-[(3,6- dimethyl-2- pyridyl)methyl]-8- me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50200981 (CHEMBL3960148 | US10138212, Example 6) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (GUINEA PIG) | BDBM50325466 (1-(3-(dimethylamino)propyl)-3-(1-(1-(pyridin-4-ylm...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brain | Bioorg Med Chem Lett 20: 5004-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.052 BindingDB Entry DOI: 10.7270/Q2N016QS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human)) | BDBM50343977 ((2R,3R)-2,3-dihydroxy-4-(isoindolin-2-yl)-4-oxo-N-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of TACE | Bioorg Med Chem Lett 20: 4812-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.104 BindingDB Entry DOI: 10.7270/Q2GX4BWK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (GUINEA PIG) | BDBM50325450 (1-(2-(dimethylamino)ethyl)-3-(1-(1-(pyridin-4-ylme...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brain | Bioorg Med Chem Lett 20: 5004-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.052 BindingDB Entry DOI: 10.7270/Q2N016QS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50201019 (CHEMBL3973920 | US10138212, Example 44) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50139773 (CHEMBL3765379 | US10138212, Example 101) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (GUINEA PIG) | BDBM50325465 (1-benzyl-3-(1-(1-(pyridin-4-ylmethyl)piperidine-4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brain | Bioorg Med Chem Lett 20: 5004-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.052 BindingDB Entry DOI: 10.7270/Q2N016QS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-K receptor (GUINEA PIG) | BDBM50116083 (3,5-Dichloro-N-[3-(3,4-dichloro-phenyl)-5-(3-dimet...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Schering Plough Research Institute Curated by ChEMBL | Assay Description In vitro binding to Tachykinin receptor 2 | Bioorg Med Chem Lett 12: 2125-8 (2002) BindingDB Entry DOI: 10.7270/Q2JQ11JS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM303248 (2-amino-N-[(1-ethyl-2- oxo-3-pyridyl)methyl]-8- me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50201006 (CHEMBL3923709 | US10138212, Example 5) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50139771 (CHEMBL3765580 | US10138212, Example 12) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SCH-58261 from human adenosine A2A receptor expressed in HEK cell membranes after 60 mins by microplate scintillation counting an... | Bioorg Med Chem Lett 26: 1348-54 (2016) Article DOI: 10.1016/j.bmcl.2015.11.048 BindingDB Entry DOI: 10.7270/Q2S46TT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50139773 (CHEMBL3765379 | US10138212, Example 101) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SCH-58261 from human adenosine A2A receptor expressed in HEK cell membranes after 60 mins by microplate scintillation counting an... | Bioorg Med Chem Lett 26: 1348-54 (2016) Article DOI: 10.1016/j.bmcl.2015.11.048 BindingDB Entry DOI: 10.7270/Q2S46TT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50139771 (CHEMBL3765580 | US10138212, Example 12) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (GUINEA PIG) | BDBM50325460 (1-(4-methoxybenzyl)-3-(1-(1-(pyridin-4-ylmethyl)pi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brain | Bioorg Med Chem Lett 20: 5004-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.052 BindingDB Entry DOI: 10.7270/Q2N016QS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-K receptor (GUINEA PIG) | BDBM50116074 (CHEMBL66635 | N-[5-(3-Carbamoylmethyl-2-oxo-[1,4']...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Schering Plough Research Institute Curated by ChEMBL | Assay Description In vitro binding to Tachykinin receptor 1 | Bioorg Med Chem Lett 12: 2125-8 (2002) BindingDB Entry DOI: 10.7270/Q2JQ11JS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50139748 (CHEMBL3763717) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SCH-58261 from human adenosine A2A receptor expressed in HEK cell membranes after 60 mins by microplate scintillation counting an... | Bioorg Med Chem Lett 26: 1348-54 (2016) Article DOI: 10.1016/j.bmcl.2015.11.048 BindingDB Entry DOI: 10.7270/Q2S46TT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (GUINEA PIG) | BDBM50325461 (1-(3-methoxybenzyl)-3-(1-(1-(pyridin-4-ylmethyl)pi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brain | Bioorg Med Chem Lett 20: 5004-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.052 BindingDB Entry DOI: 10.7270/Q2N016QS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM471619 ((R)-7-methoxy-2-(1-(3,3,3- trifluoro-2- (trifluoro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2A receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10822338 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-K receptor (GUINEA PIG) | BDBM50116091 (3,5-Dichloro-N-[3-(3,4-dichloro-phenyl)-5-(3-dimet...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Schering Plough Research Institute Curated by ChEMBL | Assay Description In vitro binding to Tachykinin receptor 2 | Bioorg Med Chem Lett 12: 2125-8 (2002) BindingDB Entry DOI: 10.7270/Q2JQ11JS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-K receptor (GUINEA PIG) | BDBM50116076 (CHEMBL441252 | N-[5-(3-Carbamoylmethyl-2-oxo-[1,4'...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Schering Plough Research Institute Curated by ChEMBL | Assay Description In vitro binding to Tachykinin receptor 2 | Bioorg Med Chem Lett 12: 2125-8 (2002) BindingDB Entry DOI: 10.7270/Q2JQ11JS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-K receptor (GUINEA PIG) | BDBM50116082 (3,5-Dichloro-N-(3-(3,4-dichloro-phenyl)-5-{3-[2-(2...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Schering Plough Research Institute Curated by ChEMBL | Assay Description In vitro binding to Tachykinin receptor 2 | Bioorg Med Chem Lett 12: 2125-8 (2002) BindingDB Entry DOI: 10.7270/Q2JQ11JS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM303280 (2-amino-N-[[6-[(4- fluorophenoxy)methyl]- 2-pyridy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM303251 (2-amino-N-(8- isoquinolylmethyl)-8- methoxy-quinaz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM303181 (2-amino-N-[(6- cyclopropyl-2- pyridyl)methyl]-8- m...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM471689 (US10822338, Example 58B) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2A receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10822338 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM471691 (US10822338, Example 35C) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2A receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10822338 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuromedin-K receptor (Homo sapiens (Human)) | BDBM50116078 (3,5-Dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by PDSP Ki Database | Eur J Pharmacol 450: 191-202 (2002) Article DOI: 10.1016/s0014-2999(02)02124-6 BindingDB Entry DOI: 10.7270/Q2862F1R | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50200989 (CHEMBL3906827 | US10138212, Example 18) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | US Patent | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM471642 (US10822338, Example 24B) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2A receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10822338 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM471649 (US10822338, Example 29C) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2A receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10822338 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM303252 (2-amino-8-methoxy-N- (m- tolylmethyl)quinazoline- ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-K receptor (GUINEA PIG) | BDBM50116078 (3,5-Dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Schering Plough Research Institute Curated by ChEMBL | Assay Description In vitro binding to Tachykinin receptor 2 | Bioorg Med Chem Lett 12: 2125-8 (2002) BindingDB Entry DOI: 10.7270/Q2JQ11JS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-P receptor (GUINEA PIG) | BDBM50116074 (CHEMBL66635 | N-[5-(3-Carbamoylmethyl-2-oxo-[1,4']...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Schering Plough Research Institute Curated by ChEMBL | Assay Description In vitro binding to Tachykinin receptor 1 | Bioorg Med Chem Lett 12: 2125-8 (2002) BindingDB Entry DOI: 10.7270/Q2JQ11JS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-K receptor (Homo sapiens (Human)) | BDBM50071112 (CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by PDSP Ki Database | Eur J Pharmacol 450: 191-202 (2002) Article DOI: 10.1016/s0014-2999(02)02124-6 BindingDB Entry DOI: 10.7270/Q2862F1R | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-K receptor (Homo sapiens (Human)) | BDBM50116078 (3,5-Dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by PDSP Ki Database | Eur J Pharmacol 450: 191-202 (2002) Article DOI: 10.1016/s0014-2999(02)02124-6 BindingDB Entry DOI: 10.7270/Q2862F1R | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-K receptor (GUINEA PIG) | BDBM50116080 (3,5-Dichloro-N-{3-(3,4-dichloro-phenyl)-2-methoxyi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Schering Plough Research Institute Curated by ChEMBL | Assay Description In vitro binding to Tachykinin receptor 2 | Bioorg Med Chem Lett 12: 2125-8 (2002) BindingDB Entry DOI: 10.7270/Q2JQ11JS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM471620 ((R)-2-(1-(2,2- difluoroethyl)piperidin-3- yl)-7-me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2A receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10822338 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-P receptor (Homo sapiens (Human)) | BDBM50110653 (3,5-Dichloro-N-[(R)-3-(3,4-dichloro-phenyl)-2-[(Z)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by ChEMBL | Assay Description Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand | Bioorg Med Chem Lett 12: 833-6 (2002) BindingDB Entry DOI: 10.7270/Q2BG2N96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50200984 (CHEMBL3932655 | US10138212, Example 9) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (GUINEA PIG) | BDBM50325473 (1-isobutyl-3-(1-(1-(pyridin-4-ylmethyl)piperidine-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brain | Bioorg Med Chem Lett 20: 5004-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.052 BindingDB Entry DOI: 10.7270/Q2N016QS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM471628 ((R)-7-methoxy-2-(1- (3,3,4,4,4- pentafluorobutyl)p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2A receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10822338 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM303298 (2-amino-8-fluoro-N-[(2- pyrazol-1- ylphenyl)methyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human)) | BDBM50343976 ((2R,3R)-2,3-dihydroxy-4-(isoindolin-2-yl)-N-((5-((...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of TACE | Bioorg Med Chem Lett 20: 4812-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.104 BindingDB Entry DOI: 10.7270/Q2GX4BWK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM471687 (US10822338, Example 57) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2A receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10822338 (2020) BindingDB Entry DOI: 10.7270/Q2KS6VMH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (GUINEA PIG) | BDBM50325448 (1-(2-morpholinoethyl)-3-(1-(1-(pyridin-4-ylmethyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brain | Bioorg Med Chem Lett 20: 5004-8 (2010) Article DOI: 10.1016/j.bmcl.2010.07.052 BindingDB Entry DOI: 10.7270/Q2N016QS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM303313 (2-amino-8-fluoro-N-[(3- fluoro-6-methyl-2- pyridyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM303284 (2-amino-N-[[6- (cyclopentylmethoxy- methyl)-2-pyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50200986 (CHEMBL3902955 | US10138212, Example 48) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Binding affinities of compounds of the invention for the human A2a receptor were determined in a competition binding assay using Scintillation Proxim... | US Patent US10138212 (2018) BindingDB Entry DOI: 10.7270/Q2WM1GGB | |||||||||||
More data for this Ligand-Target Pair |
Displayed 1 to 50 (of 2184 total ) | Next | Last >> |