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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50020052 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1363772 (CHEMBL3294189) | ||
| IC50 | 36±n/a nM | ||
| Citation |  Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56810.61 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
| Residue: | 498 | ||
| Sequence: |
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| BDBM50020052 | |||
| n/a | |||
| Name | BDBM50020052 | ||
| Synonyms: | CHEMBL3287882 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H38N2O4 | ||
| Mol. Mass. | 526.6658 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)NCCCCc1ccccc1 |r,wU:7.10,wD:4.3,(22.51,3.03,;21.2,2.23,;19.85,2.96,;21.24,.69,;19.92,-.12,;18.57,.63,;17.25,-.18,;17.29,-1.72,;18.64,-2.46,;19.96,-1.66,;15.98,-2.52,;14.63,-1.78,;13.31,-2.58,;13.35,-4.12,;14.7,-4.86,;16.01,-4.06,;12.03,-4.92,;12.07,-6.46,;10.76,-7.26,;9.4,-6.52,;8.09,-7.32,;6.74,-6.58,;6.7,-5.04,;8.02,-4.24,;9.37,-4.98,;10.68,-4.18,;8.13,-8.86,;9.47,-9.6,;6.81,-9.66,;6.84,-11.2,;5.53,-12,;5.58,-13.53,;4.27,-14.34,;4.31,-15.87,;3,-16.68,;3.05,-18.22,;4.4,-18.95,;5.72,-18.13,;5.67,-16.6,)| | ||
| Structure | 
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