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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50020054 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1363771 (CHEMBL3294188) | ||
| IC50 | 52±n/a nM | ||
| Citation |  Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50020054 | |||
| n/a | |||
| Name | BDBM50020054 | ||
| Synonyms: | CHEMBL3287890 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H30N2O4 | ||
| Mol. Mass. | 470.5595 | ||
| SMILES | OC(=O)C[C@H]1CC[C@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)Nc1ccccc1 |r,wU:7.10,4.3,(19.8,-5.61,;18.48,-6.41,;17.13,-5.67,;18.52,-7.95,;17.21,-8.75,;17.24,-10.29,;15.93,-11.08,;14.58,-10.34,;14.54,-8.8,;15.86,-8.01,;13.26,-11.14,;11.91,-10.4,;10.6,-11.2,;10.64,-12.74,;11.99,-13.48,;13.3,-12.68,;9.32,-13.54,;9.36,-15.08,;8.05,-15.88,;6.7,-15.14,;5.38,-15.94,;4.03,-15.2,;3.99,-13.66,;5.31,-12.86,;6.66,-13.6,;7.97,-12.8,;5.42,-17.48,;6.76,-18.21,;4.1,-18.28,;4.14,-19.82,;2.82,-20.61,;2.86,-22.15,;4.21,-22.89,;5.53,-22.08,;5.49,-20.55,)| | ||
| Structure | 
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