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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50020055 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1363771 (CHEMBL3294188) | ||
| IC50 | 110±n/a nM | ||
| Citation |  Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50020055 | |||
| n/a | |||
| Name | BDBM50020055 | ||
| Synonyms: | CHEMBL3287896 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C32H36N2O4 | ||
| Mol. Mass. | 512.6392 | ||
| SMILES | CCc1ccccc1NC(=O)N1CC(C)Oc2cc(ccc12)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:28.31,wD:31.35,(4.09,-13.01,;4.12,-14.54,;5.46,-15.28,;5.5,-16.82,;6.85,-17.56,;8.16,-16.75,;8.12,-15.21,;6.78,-14.49,;6.74,-12.95,;8.06,-12.14,;9.41,-12.88,;8.02,-10.6,;6.67,-9.87,;6.63,-8.33,;5.28,-7.59,;7.95,-7.52,;9.3,-8.27,;10.62,-7.46,;11.97,-8.21,;12,-9.75,;10.69,-10.54,;9.34,-9.81,;13.28,-7.4,;14.63,-8.15,;15.94,-7.34,;15.91,-5.8,;14.56,-5.07,;13.24,-5.86,;17.22,-5.01,;17.18,-3.47,;18.5,-2.66,;19.85,-3.41,;21.17,-2.6,;22.52,-3.34,;23.82,-2.53,;22.55,-4.87,;19.89,-4.95,;18.58,-5.74,)| | ||
| Structure | 
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