| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
|---|
| Ligand | BDBM50025039 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1442051 (CHEMBL3373419) |
|---|
| EC50 | 96±n/a nM |
|---|
| Citation |  Zlotos, DP; Tränkle, C; Holzgrabe, U; Gündisch, D; Jensen, AA Semisynthetic analogues of toxiferine I and their pharmacological properties ata7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors. J Nat Prod77:2006-13 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M2 |
|---|
| Name: | Muscarinic acetylcholine receptor M2 |
|---|
| Synonyms: | ACM2_PIG | CHRM2 | Cholinergic, muscarinic | GPM2 | LOC100715343 | Muscarinic acetylcholine receptor M2 | Muscarinic receptor 2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 51688.65 |
|---|
| Organism: | GUINEA PIG |
|---|
| Description: | Cholinergic, muscarinic 0 GUINEA PIG::P06199 |
|---|
| Residue: | 466 |
|---|
| Sequence: | MNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRI
VKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
|
|
|
|---|
| BDBM50025039 |
|---|
| n/a |
|---|
| Name | BDBM50025039 |
|---|
| Synonyms: | CHEMBL3337857 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C40H46Cl2N4O2 |
|---|
| Mol. Mass. | 685.725 |
|---|
| SMILES | [Cl-].[Cl-].[H][C@@]12C[C@@]3([H])\C(C[N+]1(C)CC[C@@]21c2ccccc2N2\C=C4/[C@]5([H])N(\C=C3/[C@@]12[H])c1ccccc1[C@@]51CC[N+]2(C)C\C(=C\CO)[C@]4([H])C[C@@]12[H])=C/CO |r,c:22,t:27| |
|---|
| Structure | 
|
|---|
Search and Browse
