Reaction Details |
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Target | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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Ligand | BDBM50026821 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1438249 (CHEMBL3390281) |
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IC50 | 2138±n/a nM |
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Citation | Buijnsters, P; De Angelis, M; Langlois, X; Rombouts, FJ; Sanderson, W; Tresadern, G; Ritchie, A; Trabanco, AA; VanHoof, G; Roosbroeck, YV; Andrés, JI Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target Engagement. ACS Med Chem Lett5:1049-53 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
Synonyms: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 | Phosphodiesterase 11A | Phosphodiesterase 11A (PDE11A4) | Phosphodiesterase 11A4 | cAMP and cGMP phosphodiesterase 11A |
Type: | Enzyme |
Mol. Mass.: | 104751.53 |
Organism: | Homo sapiens (Human) |
Description: | Q9HCR9 |
Residue: | 933 |
Sequence: | MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
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BDBM50026821 |
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n/a |
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Name | BDBM50026821 |
Synonyms: | CHEMBL3331521 | US11419874, Example 10 | US9669035, B-1b |
Type | Small organic molecule |
Emp. Form. | C24H28N6O2 |
Mol. Mass. | 432.5181 |
SMILES | CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccc(CN4CCOCC4)cc3n12 |
Structure |
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