Reaction Details |
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Target | Non-lysosomal glucosylceramidase |
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Ligand | BDBM50028225 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1435476 (CHEMBL3384691) |
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IC50 | 3.0±n/a nM |
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Citation | Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. J Med Chem57:9096-104 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Non-lysosomal glucosylceramidase |
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Name: | Non-lysosomal glucosylceramidase |
Synonyms: | Beta-glucosidase | GBA2 | GBA2_HUMAN | KIAA1605 | SPG46 |
Type: | PROTEIN |
Mol. Mass.: | 104639.04 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1435476 |
Residue: | 927 |
Sequence: | MGTQDPGNMGTGVPASEQISCAKEDPQVYCPEETGGTKDVQVTDCKSPEDSRPPKETDCC
NPEDSGQLMVSYEGKAMGYQVPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLR
YLQWWYRKTHVEKKTPFIDMINSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMY
QHRTVIADQFTVCLRREGQTVYQQVLSLERPSVLRSWNWGLCGYFAFYHALYPRAWTVYQ
LPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGGDD
APGGLWNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDSTGQ
QVWQDLLQDGQLDSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCRLEFSLAWDMPRIMFG
AKGQVHYRRYTRFFGQDGDAAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSAL
FNELYFLADGGTVWLEVLEDSLPEELGRNMCHLRPTLRDYGRFGYLEGQEYRMYNTYDVH
FYASFALIMLWPKLELSLQYDMALATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDD
EPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQNFLKDMWPVCLAVMESEMKFDK
DHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAALCGAQDIQDKFSSILS
RGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWFLKACGLGEGDTEVFPTQHVVR
ALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSDEVWVGVVYGLAATMIQEGLTWE
GFQTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIWAMQLALQQQQHKKASW
PKVKQGTGLRTGPMFGPKEAMANLSPE
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BDBM50028225 |
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n/a |
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Name | BDBM50028225 |
Synonyms: | CHEMBL3354045 |
Type | Small organic molecule |
Emp. Form. | C25H32N2O5 |
Mol. Mass. | 440.532 |
SMILES | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccc(cc1)C#N |r| |
Structure |
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