Reaction Details |
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Target | Transthyretin |
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Ligand | BDBM50029215 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1441631 (CHEMBL3377077) |
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EC50 | 11000±n/a nM |
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Citation | Yokoyama, T; Kosaka, Y; Mizuguchi, M Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin. J Med Chem57:8928-35 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transthyretin |
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Name: | Transthyretin |
Synonyms: | ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR) |
Type: | Enzyme |
Mol. Mass.: | 15884.31 |
Organism: | Homo sapiens (Human) |
Description: | P02766 |
Residue: | 147 |
Sequence: | MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
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BDBM50029215 |
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n/a |
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Name | BDBM50029215 |
Synonyms: | (E)-3-(3-Hydroxy-4-methoxy-phenyl)-acrylic acid phenethyl ester | 3-(3-Hydroxy-4-methoxy-phenyl)-acrylic acid phenethyl ester | CHEMBL131680 |
Type | Small organic molecule |
Emp. Form. | C18H18O4 |
Mol. Mass. | 298.3331 |
SMILES | COc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O |
Structure |
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